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Research
interests
- My group is interested in
the development of novel instrumentation for engineering biomedically relevant structures, and for
investigating cellular interactions on the microscopic scale.
- Our Bruker D3100 Atomic Force Microscope with
Dimension V controller is being used to characterize biomaterials such a
silk optics and silk scaffolds for tissue engineering.
- We have constructed a
confocal microscope with optical tweezers capability. One application is in the measurement of local material
properties by monitoring the response of a particle held in a spatially
oscillating optical tweezer trap.
- Our current collaboration
with Ana Soto at the Tufts Medical School and Irene Georgakoudi in BME has us designing an
optical tweezers based instrument which will enable the testing of
hypotheses concerning the role of extracellular matrix stiffness in the
development of mammary gland tissue. Applications include improved
understanding of the causes of breast cancer.
- Nonlinear optics of
silk-based biopolymers. Azobenzene modified silk has several nonlinear
optical properties including optically induced birefringence and real
time holographic recording via polarization gratings and optically
induced surface relief gratings. This work has recently been featured on
the cover
of the Journal of Polymer Science Part B: Polymer Physics, and written
up in Materials
Views.
Recent publications:
- “Actuation of cantilevers by optical
trapping”, P. Domachuk, E. Magi, M.
Cronin-Golomb, and B.J. Eggleton, Appl. Phys. Lett. 89,
071106 (2006)
- “Frontiers
in microphotonics: tunability
and all-optical control”, C.
Monat, C. Grillet,
P. Domachuk, C. Smith, E. Magi, D. J. Moss, H.
C. Nguyen, M. Cronin-Golomb, B. J. Eggleton,
Laser Phys. Lett. 4, 177 (2007)
- “Simple fabrication technique for rapid prototyping of seamless
cylindrical microchannels in polymer substrates”, H. Perry, C.
Greiner, Georgakoudi I, M. Cronin-Golomb, FG Omenetto,
Rev. Sci. Inst. 78,
044302 (2007)
- “Optofluidic sensing and actuation with optical
tweezers”, P.
Domachuk, F.G. Omenetto
B. J. Eggleton, M. Cronin-Golomb, J. Opt. A:
Pure Appl. Opt. 9 S129-S133
(2007)
- “Simple
fabrication technique for rapid prototyping of seamless cylindrical microchannels in polymer substrates”, H. Perry, C.
Greiner, I. Georgakoudi, M. Cronin-Golomb,
F.G. Omenetto, Rev. Sci. Inst. 78,
044302 (2007)
- “Towards
an integrated optofluidic diffractive
spectrometer”, P. Domachuk, H. Perry, M.
Cronin-Golomb, F.G. Omenetto, IEEE Phot. Tech. Lett. 19,
21 (2007)
- “Optofluidics: a novel generation of reconfigurable
and adaptive compact architectures”, C. Monat,
P. Domachuk, C. Grillet,
M. Collins, B.J. Eggleton, M. Cronin-Golomb,
S. Mutzenich, T. Mahmud, G. Rosengarten, A. Mitchell, Microfluidics and Nanofluidics, 4, 81 (2008)
- “Bioactive
silk protein biomaterial systems for optical devices”, B.D. Lawrence,
Brian D., M. Cronin-Golomb, I. Georgakoudi,
D.L. Kaplan, F.G. Omenetto, Biomacromolecules, 9, 1214 (2008)
- “On
the relationship between artificial Kerr nonlinearities and the
photorefractive effect” M. Cronin-Golomb, J. Phys. D: Appl. Phys. 41,
224001 (2008)
- “Over
4000 nm bandwidth of mid-IR supercontinuum
generation in sub-centimeter segments of highly nonlinear tellurite PCFs”, P. Domachuk,
NA Wolchover, M. Cronin-Golomb, A. Wang, A.K.
George, C.M.B. Cordeiro , J.C. Knight, F.G. Omenetto,
Opt. Express 16, 7161-7168 (2008).
- “Effect
of hollow-core photonic crystal fiber microstructure on transverse
optical trapping”, P. Domachuk, M.
Cronin-Golomb, F. G. Omenetto Appl. Phys. Lett. 94, 141101 (2009)
- “Gold
nanoparticle-doped biocompatible silk films as a path to implantable
thermo-electrically wireless powering devices”, H. Tao, S.M. Siebert,
M.A. Brenckle, R.D. Averitt, M. Cronin-Golomb,
D.L. Kaplan, F.G. Omenetto, Appl. Phys. Lett. 97, 12302 (2010)
- “Supercontinuum trap stiffness measurement using a
confocal approach”,
Z. Zhang, H.F. Li, P. Li, KB Shi, P. Edwards, F. Omenetto, M. Cronin-Golomb, G.Z. Zhang, ZW Liu, Opt.
Express, 18, 26499-26504 (2010)
- “Osteoblastic differentiation and stress response of
human mesenchymal stem cells exposed to alternating current electric
fields”, M. Hronik-Tupaj, W.L. Rice, M
Cronin-Golomb, D.L. Kaplan, I. Georgakoudi, BioMed.
Eng. OnLine, 10, 9 (2011)
- “Optically
Induced Holography and Birefringence in Silk”, M. Cronin-Golomb, A.R.
Murphy, J.P. Mondia, D.L. Kaplan, F.G. Omenetto, J. Polym. Sci., Part
B: Polym. Phys. 50, 257 (2012)
Optical Tweezers can trap not only
microspheres and biological cells, but also other objects such as the tips of
cantilevers. Possible applications include optofluidic
sensing and switching. Here is a link to a video
of fiber taper cantilever swept through optical trap
Optical
Tweezers Lab
Tufts
Scanning Probe Microscope Facility
Site updated 2/23/12
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