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Research
interests
- My
group is interested in the development of novel instrumentation for engineering
biomedically relevant structures, and for investigating cellular
interactions on the microscopic scale.
- Our
Digital Instruments D3100 Atomic Force
Microscope with Dimension V controller is being used to characterize
biomaterials such a silk optics and silk scaffolds for tissue
engineering..
- We
have constructed a confocal microscope with optical tweezers
capability. One application is in the measurement of local
material properties by monitoring the response of a particle held in a
spatially oscillating optical tweezer trap.
- In
collaboration with Agiltron
Corporation we are involved in a project on the use of photonic
bandgap engineering and nonlinear optics to make continuous wave
terahertz optical sources for biomedical imaging. We are also
researching fiber optic tapped delay lines.
- Optofluidics is
an emerging field at the interface of microfluidics and photonics. The aim is to combine photonic
circuits and microfluidic systems on the same chip so they can benefit
from each other’s strengths: integrated photonics for sensing and
actuating microfluidic systems, and microfluidic systems to tune the
optical characteristics of photonic circuits. We are currently looking
at the possibility of using optical tweezers to construct microfluidic
and optofluidic devices.
Recent publications:
- M. Cronin-Golomb
“Cascaded nonlinear difference frequency generation for enhanced
terahertz production”, Opt. Lett. 29, 2046 (2004)
- "Application of optical trapping
to beam manipulation in optofluidics" P. Domachuk, M.
Cronin-Golomb, B. Eggleton, S. Mutzenich, G. Rosengarten, and A.
Mitchell, Opt. Express 13, 7265-7275 (2005) http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-19-7265
- “Compact resonant
integrated microfluidic refractometer”
P. Domachuk, I. C. M. Littler, M. Cronin-Golomb, and B. J. Eggleton, Appl. Phys. Lett. 88, 093513
(2006)
- "Terahertz
parametric generation photonic band gap structure with negligible
structural dispersion in the optical range ," Y. Chen, M.
Cronin-Golomb, L. Zhang, J. Zhao, and J. Foshee, Opt. Express 14, 1933-1941 (2006) http://www.opticsinfobase.org/abstract.cfm?URI=oe-14-5-1933
- “Actuation of
cantilevers by optical trapping”, P. Domachuk, E. Magi, M.
Cronin-Golomb, and B.J. Eggleton, Appl. Phys. Lett. 89, 071106 (2006)
- “Frontiers in microphotonics: tunability
and all-optical control”, C. Monat, C. Grillet, P. Domachuk, C.
Smith, E. Magi, D. J. Moss, H. C. Nguyen, M. Cronin-Golomb, B. J.
Eggleton, Laser Phys. Lett. 4,
177 (2007)
- “Simple fabrication technique for rapid
prototyping of seamless cylindrical microchannels in polymer
substrates”, H. Perry, C.
Greiner, Georgakoudi I, M. Cronin-Golomb, FG Omenetto, Rev. Sci. Inst. 78, 044302 (2007)
- “Optofluidic sensing and actuation with optical
tweezers”, P. Domachuk, F.G. Omenetto B. J. Eggleton, M.
Cronin-Golomb, J. Opt. A: Pure Appl. Opt. 9 S129-S133 (2007)
- “Simple fabrication technique for rapid prototyping
of seamless cylindrical microchannels in polymer substrates”, H. Perry,
C. Greiner, I. Georgakoudi, M. Cronin-Golomb, F.G. Omenetto, Rev. Sci.
Inst. 78, 044302 (2007)
- “Towards an integrated optofluidic diffractive
spectrometer”, P. Domachuk, H. Perry, M. Cronin-Golomb, F.G. Omenetto,
IEEE Phot. Tech. Lett. 19, 21 (2007)
- “Optofluidics: a novel generation of reconfigurable
and adaptive compact architectures”, C. Monat, P. Domachuk, C. Grillet,
M. Collins, B.J. Eggleton, M. Cronin-Golomb, S. Mutzenich, T. Mahmud, G.
Rosengarten, A. Mitchell, Microfluidics and Nanofluidics, 4, 81
(2008)
- “Bioactive silk protein biomaterial systems for
optical devices”, B.D. Lawrence, Brian D., M. Cronin-Golomb, I.
Georgakoudi, D.L. Kaplan, F.G. Omenetto, Biomacromolecules, 9,
1214 (2008)
- “On the relationship between artificial Kerr
nonlinearities and the photorefractive effect” M. Cronin-Golomb, J.
Phys. D: Appl. Phys. 41, 224001 (2008)
- “Over 4000 nm bandwidth of mid-IR supercontinuum
generation in sub-centimeter segments of highly nonlinear tellurite
PCFs”, Opt. Express 16,
7161-7168 (2008)
Optical Tweezers can trap not only
microspheres and biological cells, but also other objects such as the tips of
cantilevers. Possible applications include optofluidic sensing and switching.
Here is a link to a video
of fiber taper cantilever swept through optical trap
Optical
Tweezers Lab
Tufts
Scanning Probe Microscope Facility
Comp 190 Project Spring 2004
Site updated 4/7/09
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