Mark Cronin-Golomb

Biomedical Engineering
Tufts University
4 Colby Street
Medford, MA 02155


 

 

Phone: (617)627-4355 

Fax:      (617)627-3151 

Email: mark.cronin-golomb@tufts.edu

Ph.D. from California Institute of Technology.

Research interests

  • My group is interested in the development of novel instrumentation for engineering biomedically relevant structures, and for investigating cellular interactions on the microscopic scale.
  • Our Digital Instruments D3100 Atomic Force Microscope is being used for nanolithography of collagen and other materials.
  • We have constructed a confocal microscope with optical tweezers capability.  One application is in the measurement of local material properties by monitoring the response of a particle held in a spatially oscillating optical tweezer trap.
  • In collaboration with Agiltron Corporation we are involved in a project on the use of photonic bandgap engineering and nonlinear optics to make continuous wave terahertz optical sources for biomedical imaging.  We are also researching MEMS based thermal imagers.
  • Optofluidics is an emerging field at the interface of microfluidics and photonics.  The aim is to combine photonic circuits and microfluidic systems on the same chip so they can benefit from each other’s strengths: integrated photonics for sensing and actuating microfluidic systems, and microfluidic systems to tune the optical characteristics of photonic circuits. We are currently looking at the possibility of using optical tweezers to construct microfluidic and optofluidic devices.

Recent publications:

  • Nemet B.A. and Cronin-Golomb M. "Measuring microscopic viscosity with optical tweezers as a confocal probe", Appl. Opt. 42, 1820 (2003)
  • M. Cronin-Golomb “Cascaded nonlinear difference frequency generation for enhanced terahertz production”, Opt. Lett. 29, 2046 (2004)
  •  "Application of optical trapping to beam manipulation in optofluidics" P. Domachuk, M. Cronin-Golomb, B. Eggleton, S. Mutzenich, G. Rosengarten, and A. Mitchell, Opt. Express 13, 7265-7275 (2005) http://www.opticsinfobase.org/abstract.cfm?URI=oe-13-19-7265
  • “Compact resonant integrated microfluidic refractometer”  P. Domachuk, I. C. M. Littler, M. Cronin-Golomb, and B. J. Eggleton,  Appl. Phys. Lett. 88, 093513 (2006)
  • "Terahertz parametric generation photonic band gap structure with negligible structural dispersion in the optical range ," Y. Chen, M. Cronin-Golomb, L. Zhang, J. Zhao, and J. Foshee, Opt. Express 14, 1933-1941 (2006) http://www.opticsinfobase.org/abstract.cfm?URI=oe-14-5-1933
  • “Actuation of cantilevers by optical trapping”, P. Domachuk, E. Magi, M. Cronin-Golomb, and B.J. Eggleton, Appl. Phys. Lett. 89, 071106 (2006)
  • “Frontiers in microphotonics: tunability and all-optical control”, C. Monat, C. Grillet, P. Domachuk, C. Smith, E. Magi, D. J. Moss, H. C. Nguyen, M. Cronin-Golomb, B. J. Eggleton, Laser Phys. Lett. 4, 177 (2007)
  • “Simple fabrication technique for rapid prototyping of seamless cylindrical microchannels in polymer substrates”,  H. Perry, C. Greiner, Georgakoudi I, M. Cronin-Golomb, FG Omenetto, Rev. Sci. Inst. 78, 044302 (2007)
  • “Optofluidic sensing and actuation with optical tweezers”, P. Domachuk, F.G. Omenetto B. J. Eggleton, M. Cronin-Golomb, J. Opt. A: Pure Appl. Opt. 9 S129-S133 (2007)
  • “Simple fabrication technique for rapid prototyping of seamless cylindrical microchannels in polymer substrates”, H. Perry, C. Greiner, I. Georgakoudi, M. Cronin-Golomb, F.G. Omenetto, Rev. Sci. Inst. 78, 044302 (2007)
  • “Optofluidics: a novel generation of reconfigurable and adaptive compact architectures”, C. Monat, P. Domachuk, C. Grillet, M. Collins, B.J. Eggleton, M. Cronin-Golomb, S. Mutzenich, T. Mahmud, G. Rosengarten, A. Mitchell, Microfluidics and Nanofluidics, 4, 81 (2008)
  • “Towards an integrated optofluidic diffractive spectrometer”, P. Domachuk, H. Perry, M. Cronin-Golomb, F.G. Omenetto, IEEE Phot. Tech. Lett. 19, 21 (2007)


 Optical Tweezers can trap not only microspheres and biological cells, but also other objects such as the tips of cantilevers. Possible applications include optofluidic sensing and switching. Here is a link to a  video of fiber taper cantilever swept through optical trap

 Optical Tweezers  Lab

 Tufts Scanning Probe Microscope Facility

Comp 190 Project Spring 2004
 
  Site updated 4/29/08